PMMA IOL
Material: Polymethyl methacrylate (PMMA)
First implantation: 1949, Sir Harold Ridley
Features: Rigid lens. Requires large incision.
Cataract is a disease in which the lens becomes cloudy, causing vision loss. The word originates from the Latin “cataracta” (waterfall). This is based on the ancient belief that an opaque fluid flows within the lens, or that severe cataracts resemble a waterfall.
Cataract is the leading cause of blindness worldwide. As of 2010, over 20 million people were affected, and the prevalence continues to increase with the aging population. For cataracts with visual impairment, surgical intervention is the only curative treatment.
The history of cataract surgery dates back to ancient times. It has been a continuous series of technological innovations, starting with ancient couching, followed by extracapsular cataract extraction in the 18th century, intraocular lenses and phacoemulsification in the 20th century, and laser surgery in the 21st century.
Couching is the oldest surgical technique for cataracts. The term comes from the French word “coucher” (to lay down). It involved puncturing the eye near the corneal edge with a sharp needle and dislodging the cloudy lens out of the visual axis.
The following ancient records are known:
However, in an era without the concept of aseptic technique, the prognosis was extremely poor. Major complications included secondary glaucoma, hyphema, and endophthalmitis, often leading to blindness. Couching is still practiced in northern Nigeria and parts of West Africa today.
There was no concept of aseptic technique, and the procedure was crude. Since the lens was only displaced from the visual axis and not removed, complications such as secondary glaucoma, hyphema, and endophthalmitis frequently occurred.
Archaeological evidence suggests that aspiration of soft cataracts may have been performed in ancient Greek and Roman times. In medieval Arabia (10th–17th centuries), cataract extraction via tube aspiration was definitely performed.
The founder of modern extracapsular cataract extraction is the French surgeon Jacques Daviel. In 1745 (or 1750 according to some sources), Daviel performed the first planned extracapsular cataract extraction through an inferior incision.
Daviel’s technique was as follows:
Although it was a significant improvement over couching, complications such as posterior capsule opacification, retained lens material, and infection remained prevalent.
| Period | Procedure | Characteristics |
|---|---|---|
| Ancient–18th century | Couching | Dislocation of the lens out of the visual axis |
| 1745– | Extracapsular cataract extraction | Removal of the lens through a corneal incision |
| 1753– | ICCE | Removal of the entire lens within the capsule |
In 1753, London surgeon Samuel Sharp first recorded intracapsular cataract extraction (ICCE). This technique removes the cloudy lens and its surrounding capsule as a single unit. The zonular fibers are severed, and the lens capsule complex is extracted through a large corneal incision.
In the 1850s, von Graefe performed extracapsular cataract extraction using a linear knife through a superior incision, and also performed intracapsular extraction using capsule forceps.
The main problems with ICCE were as follows:
In 1884, Austrian physician Carl Koller introduced topical cocaine anesthesia for eye surgery. This greatly improved pain management during cataract surgery. In 1919, Elschnig introduced retrobulbar anesthesia, and in 1993, Fishman reported the use of topical anesthesia.
After lens removal, patients become aphakic. Before IOLs, high-power bulky glasses were needed, greatly reducing visual quality.
In 1797, Casamata of Dresden attempted to place a glass intraocular lens after cataract surgery. However, the lens fell to the back of the eye, resulting in failure.
In 1949, Sir Harold Ridley performed the world’s first IOL implantation at St. Thomas’ Hospital in London. Stating that “removal alone is only half the treatment for cataracts,” Ridley observed during World War II that plastic fragments (PMMA) retained in the eyes of British Royal Air Force pilots caused almost no reaction. This finding led to the development of the PMMA IOL.
The initial IOLs were larger and heavier than current ones, often causing them to sink into the eye.
At that time, the concept of IOL itself was revolutionary, and there was strong criticism against inserting a foreign body into the eye. Complications such as glaucoma, inflammation, IOL dislocation, and difficulty in refractive power adjustment occurred, but Ridley’s innovation became the foundation of modern IOL technology.
PMMA IOL
Material: Polymethyl methacrylate (PMMA)
First implantation: 1949, Sir Harold Ridley
Features: Rigid lens. Requires large incision.
Foldable IOL
Material: Silicone (early), acrylic, etc.
First implantation: 1978, Zhou Kaiyi
Advantages: Can be inserted through a small incision. Postoperative astigmatism and infection are reduced.
In 1978, Kai-yi Zhou performed the first implantation of a silicone foldable IOL. Foldable IOLs allowed insertion through a small incision, providing the following advantages:
After lens extraction, aphakic eyes were prescribed high-power convex lens glasses. However, visual quality was greatly reduced due to visual field distortion and image magnification.
In 1967, Charles Kelman developed phacoemulsification. This technique uses ultrasound to break up the cataract and aspirate it from the eye. This technological innovation led to the following advances:
The modern standard procedure is as follows:
| Surgical technique | Incision size | Main era |
|---|---|---|
| Extracapsular cataract extraction (conventional) | 10 mm or more | 18th century~ |
| ICCE | 10mm or more | 1753~ |
| Phacoemulsification | Less than 3mm | 1967~ |
As an evolution of extracapsular cataract extraction, sutureless small incision cataract surgery (MSICS / SICS / SECCE) was developed. The incision is self-sealing and does not require sutures. Compared to phacoemulsification, it is less costly and requires less advanced skills, so it is mainly used in developing countries.
The biggest change was that the incision size was reduced from 10 mm to less than 3 mm. This led to a significant reduction in postoperative recovery time and a decrease in complication rates.
FLACS received FDA approval in the United States in 2010. The femtosecond laser is equipped with imaging capabilities for the cornea, lens capsule, and anterior chamber, and automates the following procedures:
It is particularly useful when inserting premium lenses such as toric IOLs and multifocal/trifocal IOLs.
Modern cataract surgery is extremely safe and effective, and further refinement is being pursued.
FLACS has advantages in precision of corneal incisions and capsulotomy. However, there is currently no definitive conclusion on its superiority over conventional methods, and decisions are made on a case-by-case basis considering cost and indications.